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AKADEMİK ÇIKTI

Bilimsel Makaleler

Dr. Solaroğlu'nun mükemmel yayın geçmişi, nörobilim ve kanser alanındaki uzmanlığını kanıtlıyor. 80'den fazla makale yazdı veya ortak yazar oldu. Makalelerine 3600'den fazla alıntı yapılmıştır (h-endeksi: 33- Google Akademik, 2000 alıntı ve h-index: 24- WOS). Projeleri, Türkiye Sağlık Enstitüleri (TÜSEB), Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (TÜBİTAK) ve Avrupa Komisyonu (EC) dahil olmak üzere ulusal ve uluslararası kuruluşlar tarafından 12 milyon USD'den fazla destek aldı. Dr. Solaroğlu'nun başlıca ve en son yayınları aşağıdadır;

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  1. Parlatan U, Ozen MO, Kecoglu I, Koyuncu B, Torun H, Khalafkhany D, Loc I, Ogut MG, Inci F, Akin D, Solaroglu I, Ozoren N, Unlu MB, Demirci U. Label-Free Identification of Exosomes using Raman Spectroscopy and Machine Learning. Small. 2023 Jan 15:e2205519.

  2. Aydin SO, Erdem IS, Kose SG, Solaroglu I. The possible effects of sodium fluoroscein to primary cell culture sampling in glioblastoma surgery. Brain Spine. 2022 Dec 17;3:101702.

  3. Kayabolen A, Akcan U, Ozturan D, Ulbegl-Polat H, Sahin GN, Pinarbasi-Degirmenci N, Bayraktar C, Soyler G, Sarayloo E, Nurtop E, Ozer B, Guney-Esken G, Barlas T, Yıldırım IS, Dogan O, Karahuseyinoglu S, Lack NA, Kaya M, Albayrak C, Can F, Solaroglu I, Bagci-Onder T. Protein scaffold-based multimerization of soluble ACE2 efficiently blocks SARS-CoV-2 infection in vitro and in vivo. Advanced Science 2022 DOI: 10.1002/advs.202201294

  4. Pinarbasi-Degirmenci N, Sur-Erdem I, Akcay V, Bolukbasi Y, Selek U, Solaroglu I, Bagci-Onder T. Chronically Radiation-Exposed Survivor Glioblastoma Cells Display Poor Response to Chk1 Inhibition under Hypoxia. Int J Mol Sci 2022 Jun 24;23(13):7051.

  5. Esene IN, Negida A, Ibe CS, Kanmounye US, Thango N, Jokonya L, Hoz SS, Dechambenoit G, Kalangu KKN, Solaroglu I. Observational Studies in Neurosurgery: Structure, Functioning, and Uses. World Neurosurg. 2022 May; 161:265-274.

  6. Seker-Polat F, Pinarbasi Degirmenci N, Solaroglu I, Bagci-Onder T. Tumor Cell Infiltration into the Brain in Glioblastoma: From Mechanisms to Clinical Perspectives. Cancers (Basel). 2022 Jan 17;14(2):443.

  7. Cingöz A, Ozyerli-Goknar E, Morova T, Seker-Polat F, Esai Selvan M, Gümüş ZH, Bhere D, Shah K, Solaroglu I, Bagci-Onder T. Generation of TRAIL-resistant cell line models reveals distinct adaptive mechanisms for acquired resistance and re-sensitization. T. Oncogene. 2021 May;40(18):3201-3216.

  8. Kulle CB, Azamat IF, Vatansever D, Erus S, Tarim K, Akyoldas G, Gokler O, Deveci MA, Cakar N, Ergonul O, Agcaoglu O, Kiremit MC, Yavuz O, Kiris T, Unsaler S, Giray B, Korkmaz M, Dilege E, Kilic M, Cesur E, Solaroglu I, Altuntas O, Simsek A, Tanju S, Erkan M, Canda E, Sasani M, Hafiz AM, Kordan Y, Balik E, Bilge O, Bugra D, Taskiran C, Dilege S. Is elective cancer surgery feasible during the lock-down period of the COVID-19 pandemic? Analysis of a single institutional experience of 404 consecutive patients. J Surg Oncol 2021 Jun;123(7):1495-1503.

  9. Senbabaoglu F, Aksu AC, Cingoz A, Seker-Polat F, Borklu-Yucel E, Solaroglu İ, Bagci-Onder T. Drug Repositioning Screen on a New Primary Cell Line Identifies Potent Therapeutics for Glioblastoma. Front Neurosci. 2020 Dec 17; 14:578316.

  10. Karahuseyinoglu S, Sekerdag E, Aria MM, Cetin Tas Y, Nizamoglu S, Solaroglu I, Gürsoy-Özdemir Y. Three-dimensional neuron-astrocyte construction on matrigel enhances establishment of functional voltage-gated sodium channels. J Neurochem. 2021 Mar;156(6):848-866.

  11. Sur-Erdem I, Muslu K, Pınarbası N, Altunbek M, Seker-Polat F, Cingöz A, Aydın SO, Kahraman M, Culha M, Solaroglu I, Bagcı-Önder T. TRAIL-conjugated silver nanoparticles sensitize glioblastoma cells to TRAIL by regulating CHK1 in the DNA repair pathway. Neurol Res. 2020 Dec;42(12):1061-1069.

  12. Erbil D, Eren CY, Demirel C, Küçüker MU, Solaroglu I, Eser HY. GLP-1's role in neuroprotection: a systematic review. Brain Inj. 2019;33(6):734-819.

  13. Taş YÇ, Solaroglu I, Gürsoy-Özdemir Y. Spreading Depolarization Waves in Neurological Diseases: A Short Review about its Pathophysiology and Clinical Relevance. Curr Neuropharmacol. 2019;17(2):151-164.

  14. Akyol O, Sherchan P, Yilmaz G, Reis C, Ho WM, Wang Y, Huang L, Solaroglu I, Zhang JH. Neurotrophin-3 provides neuroprotection via TrkC receptor dependent pErk5 activation in a rat surgical brain injury model. Exp Neurol. 2018 Sep; 307:82-89.

  15. Sekerdag E, Solaroglu I, Gursoy-Ozdemir Y. Cell Death Mechanisms in Stroke and Novel Molecular and Cellular Treatment Options. Curr Neuropharmacol. 2018;16(9):1396-1415.

  16. Akyol GY, Manaenko A, Akyol O, Solaroglu I, Ho WM, Ding Y, Flores J, Zhang JH, Tang J. IVIG activates FcγRIIB-SHIP1-PIP3 Pathway to stabilize mast cells and suppress inflammation after ICH in mice. Sci Rep. 2017 Nov 14;7(1):15583.

  17. Mansouri S, Singh S, Alamsahebpour A, Burrell K, Li M, Karabork M, Ekinci C, Koch E, Solaroglu I, Chang JT, Wouters B, Aldape K, Zadeh G. DICER governs characteristics of glioma stem cells and the resulting tumors in xenograft mouse models of glioblastoma. Oncotarget. 2016 Aug 30;7(35):56431-56446.

  18. Mansouri S, Nejad R, Karabork M, Ekinci C, Solaroglu I, Aldape KD, Zadeh G. Sox2: regulation of expression and contribution to brain tumors. CNS Oncol. 2016 Jul;5(3):159-73

  19. Yapıcı-Eser H, Onay A, Öztop-Çakmak Ö, Egemen E, Vanlı-Yavuz EN, Solaroglu I. Rare case of glioblastoma multiforme located in posterior corpus callosum presenting with depressive symptoms and visual memory deficits. BMJ Case Rep. 2016 Dec 15;2016

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GENERATION OF TRAIL-RESISTANT CELL LINE MODELS

Oncogene​ 2021 May;40(18):3201-3216.

doi: 10.1038/s41388-021-01697-6. 

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Our findings provide new models of acquired TRAIL resistance, which will provide essential tools to gain further insight into the heterogeneous therapy responses within GBM tumors. Additionally, these findings emphasize the critical importance of combining proteasome inhibitors and pro-apoptotic ligands to overcome acquired resistance.

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LABEL-FREE IDENTIFICATION OF EXOSOMES

Small​ 2023 Mar;19(9):e2205519.

doi: 10.1002/smll.202205519.

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This machine learning-assisted SERS method enables a new direction through label-free investigation of EV preparations by differentiating cancer cell-derived exosomes from those of healthy. This approach will potentially open up new avenues of research for early detection and monitoring of various diseases, including cancer.

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THE POSSIBLE EFFECTS OF SODIUM FLUOROSCEIN IN GLIOMA SURGERY

Brain Spine. 2022 Dec 17;3:101702.

doi: 10.1016/j.bas.2022.101702.

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Primary GB cell (GC) cultures have become a crucial tool in the research of brain tumors, with the potential of revealing patient-specific variations in therapeutic response. Unfortunately, quantitative data on the stability of these cells over the first 20–30 passes of culture are few. 

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